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How many platelets are in circulation?
140–340,000 microliters
What does platelet degranulate?
serotonin, histamin, Platelet Derived Growth Factors (promote proliferation of connective tissue)
What phase of asthma do platelets contribute to?
first phase, generate thromboxane and PAF (PAF recruit eisonophils into bronchial mucosa)
What is needed for pavementation?
Ca 2+, TNF, LTB, IL
In pavementing, there are adhesion molecules on leukocyte (______) and endothelium (_______ family of adhesion molecules)
integrin, selectin
Normal WBC count?
4000–10,000 microliters
Where do PMNs come from?
bone
In TB, what type of WBC in granuloma?
lymphocytes
In parasites, what type of WBC in granuloma?
eisonophils
In fungal, what type of WBC in granuloma?
neutrophils
______ to pituitary gland stimulates adrenal gland via increase in ACTH to increase output of glucocorticoids.
cytokines (IL–1)
What has antinflammatory effects?
glucocorticoids (can depress protein synth)