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English
GCSF play a major role in?
PMN production and maturation
colony stimulating factors made from?
endothelial cells, fibroblasts, macrophages, etc.
lymphokines produced by in response to antigenic stimulation?
T–cells
What two things can the immune system activate?
mast cell degranulation and complement
stages of inflammation are cytokines involved in?
initiation, cell recruitment, debris removal, repai
plasma proteins?
complement, clotting, fibrinolytic, kinin, immune
2 complement pathways?
classical or alternative/lecithin pathway (all involve C3)
functions of the complement system?
chemotactic, lyse bacteria, opsonins, vasodilate, increase permeability, anaphylatoxins (degranulate mast cells), can stimulate leukocytosis
main substance produced in clotting cascade?
fibrin
main enzyme in clotting cascade?
thrombin
What activated clotting system?
bacteria, tissue damage, kinins, HF (stim by both intrinsic and extrinsic pathways)
Difference between intrinsic and extrinsic pathways of clotting system?
intrinsic has injury, blood in contact with collagen and act. HF while extrinsic involves platelet/tissue damage and then thromboplatic