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English
Where are adult stem cells found?
In niches (eg, isthmus of gastric glands, base of colonic crypts, limbus of cornea)
What are the two major classes of effect of growth factors?
transcription of genes that were silent in resting cells; regulate cell entry into and passage thru the cell cycle.
T/F Large molecules can also pass thru gap junctions
False.
Example of autocrine signaling
Growth factors on epithelial cells
Example of paracrine signaling
inflammatory cells in infection sites; wound healing process
What are the most important factors for cell growth and differentiation?
Polypeptide growth factors (PGF), either circulating in serum or produced by local cells. Have pleiotropic effects
pleiotropic : defn
occurs when a single gene influences multiple phenotypic traits.
What is compensatory hyperplasia?
Process by which remaining cells proliferate to reconstitute functional mass of an organ (eg., liver). Entire lobes aren't replaced after partial hepatectomy.
T/F ECM must remain intact for the parenchyma to heal
T
what's the most abundant component of healing scars?
collagens
How does collagen confer tensile strength?
Extensive crosslinking
What gives recoil to tissues?
elastin