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What vascular endothelial cells do interleukins act on?
NO, vasodilator
What inhibits IL production and activity?
glucocorticoids and gold compounds
types of interferons are there?
IFN alpha– cathectin, and interferon gamma and beta
Interferons are inducible and are synesized in response to what stimuli?
viral
widest acting cytokine?
TGF
TGF increase?
interleukin production
TGF mediate?
proliferation, differentiation, angiogenesis, cell migration and adherence
TGF stimulate for wound healing and collagen production?
fibroblasts
TNF increase?
cytokine (IL) production, phagocyte activity, PGI2 synthesis in endothelial cells
TNF important in?
endotoxic shock
TNF envolved in angiogenesis?
enhances it
2 types of colony stimulating factors?
GCSF (granuloctye) and GMCSF (granulocyte macrophage)