Converts hydrogen peroxide to bleach during respiratory burst to kill microbes that have been phagocytosed.
An azurophil is an object readily stained with an azure dye. [1] Azurophils include certain cytoplasmic granules[2] in white blood cells and hyperchromatin, imparting a burgundy or merlot coloration. Neutrophils in particular are known for containing azurophils loaded with a wide variety of anti–microbial defensins that fuse with phagocytic vacuoles.
MPO (azophilic granules) converts hydrogen peroxide to HOCl– (bleach!) that is very destructive to microbes
Oxygen–dependent mechanisms that are stimulated by phagocytosis. Rseults in production of reactive oxygen species in phagolysosomes. Can make hydrogen peroxide OR bleach
Cytoplasm flows around a particle ––> phagosome vacuole. This fuses with lysosome ––> phagolysosome. Phagolysosome granules discharge.
IgG antibodies; mannose–binding lectin; C3b (complement)
1) Recognition and attachment: based on what's attached to the surface 2) Engulfment 3) Killing and degradation
Complement components, cytokines, lipoxygenase, arachidonic acid metabolites, soluble components of bacteria
Complementary adhesion molecules: selectins, integrins, ICAMs, CD31
concentration of red blood cells in small vessels
transudate
pus