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English
Ability of drug to produce the maximal biologic effect
Efficacy
Inhibitors of CYP450
Macrolides, ketoconazole (azoles), ritonavir (protease inhibitors), cimetadine, grapefruit juice, quinidine, amiodarone
Inducers of CYP450
Rifampin, phenobarbital, carbamazepine, phenytoin, St. Johns wort
Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs)
Half–life (T1/2)
Mechanism of action utilizes transmembrane receptors that have intrinsic enzymatic activity
Insulin, EGF, TGFbeta, PDGF, ANP
Mechanism of action utilizes intracellular receptors
Steroid and hormones
Ability of drug to produce the maximal biologic effect
Efficacy
Inhibitors of CYP450
Macrolides, ketoconazole (azoles), ritonavir (protease inhibitors), cimetadine, grapefruit juice, quinidine, amiodarone
Inducers of CYP450
Rifampin, phenobarbital, carbamazepine, phenytoin, St. Johns wort
Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs)
Half–life (T1/2)